Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes.
نویسندگان
چکیده
Axially chiral biaryls were synthesized by an isoquinoline or 2-pyridine-directed Rh(III)-catalyzed dual C-H cleavage and coupling with internal alkynes in good to excellent yields. Oxidation of isoquinoline derivatives with m-CPBA furnished their corresponding N-oxides, which could be utilized as Lewis base catalysts in asymmetric reactions.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 60 شماره
صفحات -
تاریخ انتشار 2014